Cargando…

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

BACKGROUND: Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the Huntingtin (HTT) gene. Proteolytic cleavage of mutant huntingtin (Htt) protein with an expanded polyglutamine (polyQ) stretch results in production of Htt fragments that aggregate and induce...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Hagen, Martijn, Piebes, Diewertje G. E., de Leeuw, Wim C., Vuist, Ilona M., van Roon-Mom, Willeke M. C., Moerland, Perry D., Verschure, Pernette J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429582/ https://www.ncbi.nlm.nih.gov/pubmed/28499347 http://dx.doi.org/10.1186/s12864-017-3745-z

Ejemplares similares

The MID1 Protein: A Promising Therapeutic Target in Huntington’s Disease
por: Heinz, Annika, et al.
Publicado: (2021)

A Role for MeCP2 in Switching Gene Activity via Chromatin Unfolding and HP1γ Displacement
por: Brink, Maartje C., et al.
Publicado: (2013)

Juvenile‐Onset Huntington Disease Pathophysiology and Neurodevelopment: A Review
por: Bakels, Hannah S., et al.
Publicado: (2021)

Statistical method for modeling sequencing data from different technologies in longitudinal studies with application to Huntington disease
por: Fuady, Angga M., et al.
Publicado: (2020)

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain
por: Mina, Eleni, et al.
Publicado: (2016)

Post‐mortem 7T MR imaging and neuropathology in middle stage juvenile‐onset Huntington disease: A case report
por: Bakels, Hannah S., et al.
Publicado: (2022)

Pathological characterization of T2*-weighted MRI contrast in the striatum of Huntington’s disease patients
por: Bulk, Marjolein, et al.
Publicado: (2020)

Making (anti-) sense out of huntingtin levels in Huntington disease
por: Evers, Melvin M, et al.
Publicado: (2015)

Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset
por: Gardiner, Sarah L., et al.
Publicado: (2018)

Machine learning in Huntington’s disease: exploring the Enroll-HD dataset for prognosis and driving capability prediction
por: Ouwerkerk, Jasper, et al.
Publicado: (2023)

Candidate methylation sites associated with endocrine therapy resistance in ER+/HER2- breast cancer
por: Soleimani Dodaran, Maryam, et al.
Publicado: (2020)

Co-expression Patterns between ATN1 and ATXN2 Coincide with Brain Regions Affected in Huntington’s Disease
por: Keo, Arlin, et al.
Publicado: (2017)

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
por: van Roon-Mom, Willeke MC, et al.
Publicado: (2008)

Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood
por: Mastrokolias, Anastasios, et al.
Publicado: (2015)

Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington’s disease peripheral blood samples
por: Mastrokolias, Anastasios, et al.
Publicado: (2016)

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3
por: Toonen, Lodewijk J. A., et al.
Publicado: (2016)

Spatial Relationship between Transcription Sites and Chromosome Territories
por: Verschure, Pernette J., et al.
Publicado: (1999)

GLUT-1 changes in paediatric Huntington disease brain cortex and fibroblasts: an observational case-control study
por: Tramutola, Antonella, et al.
Publicado: (2023)

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates
por: Schut, Menno H., et al.
Publicado: (2017)

Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies
por: Evers, Melvin M., et al.
Publicado: (2013)

Mechanistic stochastic model of histone modification pattern formation
por: Anink-Groenen, Lisette C M, et al.
Publicado: (2014)

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice
por: Toonen, Lodewijk J.A., et al.
Publicado: (2017)

The volumes and transcript counts of single cells reveal concentration homeostasis and capture biological noise
por: Kempe, Hermannus, et al.
Publicado: (2015)

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease
por: Hensman Moss, Davina J., et al.
Publicado: (2017)

Genetics, Mechanisms, and Therapeutic Progress in Polyglutamine Spinocerebellar Ataxias
por: Buijsen, Ronald A.M., et al.
Publicado: (2019)

Antisense-Mediated RNA Targeting: Versatile and Expedient Genetic Manipulation in the Brain
por: Zalachoras, Ioannis, et al.
Publicado: (2011)

Therapeutic Strategies for Spinocerebellar Ataxia Type 1
por: Kerkhof, Laurie M. C., et al.
Publicado: (2023)

Osteopontin and phospho‐SMAD2/3 are associated with calcification of vessels in D‐CAA, an hereditary cerebral amyloid angiopathy
por: Grand Moursel, Laure, et al.
Publicado: (2019)

Simultaneous Integration of Gene Expression and Nutrient Availability for Studying the Metabolism of Hepatocellular Carcinoma Cell Lines
por: Weglarz-Tomczak, Ewelina, et al.
Publicado: (2021)

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
por: Osmand, Alexander P., et al.
Publicado: (2016)

Time-Resolved Profiling Reveals ATF3 as a Novel Mediator of Endocrine Resistance in Breast Cancer
por: Borgoni, Simone, et al.
Publicado: (2020)

Human Induced Pluripotent Stem Cell-Based Modelling of Spinocerebellar Ataxias
por: Hommersom, Marina P., et al.
Publicado: (2021)

Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
por: Mastrokolias, Anastasios, et al.
Publicado: (2012)

Exploring the Transcriptome of Ciliated Cells Using In Silico Dissection of Human Tissues
por: Ivliev, Alexander E., et al.
Publicado: (2012)

Preparing n-of-1 Antisense Oligonucleotide Treatments for Rare Neurological Diseases in Europe: Genetic, Regulatory, and Ethical Perspectives
por: Synofzik, Matthis, et al.
Publicado: (2022)

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease
por: Highet, Blake, et al.
Publicado: (2020)

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes
por: de Groote, Marloes L., et al.
Publicado: (2012)

Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia
por: Kenkhuis, Boyd, et al.
Publicado: (2022)

Factors Affecting Aggregate Formation in Cell Models of Huntington’s Disease and Amyotrophic Lateral Sclerosis
por: Lazarev, V. F., et al.
Publicado: (2013)

Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain
por: Toonen, Lodewijk J.A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t3gojj5gl12g5ph7272c7k7282