Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout

Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Here, we characterize verinurad (RDEA3170), which is currently under evaluation for gout therapy. Verinurad specifically inhibits URAT1 with a potency of 25 nM. High affinity inh...

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Detalles Bibliográficos
Autores principales: Tan, Philip K., Liu, Sha, Gunic, Esmir, Miner, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429603/
https://www.ncbi.nlm.nih.gov/pubmed/28386072
http://dx.doi.org/10.1038/s41598-017-00706-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429603/
https://www.ncbi.nlm.nih.gov/pubmed/28386072
http://dx.doi.org/10.1038/s41598-017-00706-7

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