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The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
The conversion of globular proteins into amyloid fibrils is associated with a wide variety of human diseases. One example is the prion protein (PrP), which adopts an α-helical structure in the native state but its amyloid form is implicated in the pathogenesis of prion diseases. Previous evidence ha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429628/ https://www.ncbi.nlm.nih.gov/pubmed/28373719 http://dx.doi.org/10.1038/s41598-017-00710-x |