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Recombinant Slit2 Reduces Surgical Brain Injury Induced Blood Brain Barrier Disruption via Robo4 Dependent Rac1 Activation in a Rodent Model

Brain tissue surrounding surgical resection site can be injured inadvertently due to procedures such as incision, retractor stretch, and electrocauterization when performing neurosurgical procedures, which is termed as surgical brain injury (SBI). Blood brain barrier (BBB) disruption due to SBI can...

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Detalles Bibliográficos
Autores principales: Sherchan, Prativa, Huang, Lei, Akyol, Onat, Reis, Cesar, Tang, Jiping, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429690/
https://www.ncbi.nlm.nih.gov/pubmed/28389649
http://dx.doi.org/10.1038/s41598-017-00827-z