Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice

The tuberous sclerosis complex 1/2 (TSC1/2) is an endogenous regulator of the mechanistic target of rapamycin (mTOR). While mTOR has been shown to play an important role in health and aging, the role of TSC1/2 in aging has not been fully investigated. In the current study, a constitutive TSC1 transg...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hong-Mei, Diaz, Vivian, Walsh, Michael E., Zhang, Yiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429778/
https://www.ncbi.nlm.nih.gov/pubmed/28400571
http://dx.doi.org/10.1038/s41598-017-00970-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429778/
https://www.ncbi.nlm.nih.gov/pubmed/28400571
http://dx.doi.org/10.1038/s41598-017-00970-7

Ejemplares similares