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Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice
The tuberous sclerosis complex 1/2 (TSC1/2) is an endogenous regulator of the mechanistic target of rapamycin (mTOR). While mTOR has been shown to play an important role in health and aging, the role of TSC1/2 in aging has not been fully investigated. In the current study, a constitutive TSC1 transg...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429778/ https://www.ncbi.nlm.nih.gov/pubmed/28400571 http://dx.doi.org/10.1038/s41598-017-00970-7 |