A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1

The Caenorhabditis elegans clk-1 gene and the orthologous mouse gene Mclk1 encode a mitochondrial hydroxylase that is necessary for the biosynthesis of ubiquinone (UQ). Mutations in these genes produce broadly pleiotropic phenotypes in both species, including a lengthening of animal lifespan. A numb...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ju-Ling, Yee, Callista, Wang, Ying, Hekimi, Siegfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429816/
https://www.ncbi.nlm.nih.gov/pubmed/28404998
http://dx.doi.org/10.1038/s41598-017-00754-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429816/
https://www.ncbi.nlm.nih.gov/pubmed/28404998
http://dx.doi.org/10.1038/s41598-017-00754-z

Ejemplares similares