5,7-Dihydroxyflavone Analogues May Regulate Lipopolysaccharide-Induced Inflammatory Responses by Suppressing IκBα-Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages

We studied the anti-inflammatory activity of twelve 5,7-dihydroxyflavone analogues in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages. We found that chrysin (1) and 4′-methoxytricetin (9) showed relatively significant anti-inflammatory activity and low cytotoxicity. Moreover, 1 and 9 rec...

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Detalles Bibliográficos
Autores principales: Nishina, Atsuyoshi, Shimizu, Kazue, Koketsu, Mamoru, Ninomiya, Masayuki, Sato, Daisuke, Suzuki, Takashi, Hayakawa, Satoshi, Kimura, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429937/
https://www.ncbi.nlm.nih.gov/pubmed/28539967
http://dx.doi.org/10.1155/2017/7898973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429937/
https://www.ncbi.nlm.nih.gov/pubmed/28539967
http://dx.doi.org/10.1155/2017/7898973

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