Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms

Mammalian Na(+)/Ca(2+) exchangers, NCX1 and NCX3, generate splice variants, whereas NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12), where Ca(2+) binding to CBD1 activates and Ca(2+) binding to CBD2 (bearing the splicing segment) alleviates the Na(+)-induced inactivation. H...

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Detalles Bibliográficos
Autores principales: Giladi, Moshe, Lee, Su Youn, Ariely, Yarden, Teldan, Yotam, Granit, Rotem, Strulovich, Roi, Haitin, Yoni, Chung, Ka Young, Khananshvili, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430519/
https://www.ncbi.nlm.nih.gov/pubmed/28428550
http://dx.doi.org/10.1038/s41598-017-01102-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430519/
https://www.ncbi.nlm.nih.gov/pubmed/28428550
http://dx.doi.org/10.1038/s41598-017-01102-x

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