Aminoglycosides, but not PTC124 (Ataluren), rescue nonsense mutations in the leptin receptor and in luciferase reporter genes

In rare cases, monogenetic obesity is caused by nonsense mutations in genes regulating energy balance. A key factor herein is the leptin receptor. Here, we focus on leptin receptor nonsense variants causing obesity, namely the human W31X, murine Y333X and rat Y763X mutations, and explored their susc...

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Detalles Bibliográficos
Autores principales: Bolze, Florian, Mocek, Sabine, Zimmermann, Anika, Klingenspor, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430635/
https://www.ncbi.nlm.nih.gov/pubmed/28432296
http://dx.doi.org/10.1038/s41598-017-01093-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430635/
https://www.ncbi.nlm.nih.gov/pubmed/28432296
http://dx.doi.org/10.1038/s41598-017-01093-9

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