Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility

Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the glyoxylate shunt. In the present investigation, we studied the conformational flexibility of MtbICL to better understand its stability and catalytic activity. Our biochemical results showed that a point...

Descripción completa

Detalles Bibliográficos
Autores principales: Shukla, Harish, Shukla, Rohit, Sonkar, Amit, Pandey, Tripti, Tripathi, Timir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430663/
https://www.ncbi.nlm.nih.gov/pubmed/28432345
http://dx.doi.org/10.1038/s41598-017-01235-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430663/
https://www.ncbi.nlm.nih.gov/pubmed/28432345
http://dx.doi.org/10.1038/s41598-017-01235-z

Ejemplares similares