Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase

The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of activating transcription factor 4 (ATF4) in controlling the hep...

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Detalles Bibliográficos
Autores principales: Al-Baghdadi, Rana J. T., Nikonorova, Inna A., Mirek, Emily T., Wang, Yongping, Park, Jinhee, Belden, William J., Wek, Ronald C., Anthony, Tracy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430736/
https://www.ncbi.nlm.nih.gov/pubmed/28455513
http://dx.doi.org/10.1038/s41598-017-01041-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430736/
https://www.ncbi.nlm.nih.gov/pubmed/28455513
http://dx.doi.org/10.1038/s41598-017-01041-7

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