Cargando…

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase

The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1). The study objective was to investigate the protective role of activating transcription factor 4 (ATF4) in controlling the hep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Baghdadi, Rana J. T., Nikonorova, Inna A., Mirek, Emily T., Wang, Yongping, Park, Jinhee, Belden, William J., Wek, Ronald C., Anthony, Tracy G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430736/ https://www.ncbi.nlm.nih.gov/pubmed/28455513 http://dx.doi.org/10.1038/s41598-017-01041-7

Ejemplares similares

Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific
por: Jonsson, William O., et al.
Publicado: (2022)

Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver
por: Fusakio, Michael E., et al.
Publicado: (2016)

BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin
por: Park, Jinhee, et al.
Publicado: (2019)

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
por: Cordova, Ricardo A, et al.
Publicado: (2022)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells
por: Purwaha, Preeti, et al.
Publicado: (2014)

Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex
por: Jonsson, William O, et al.
Publicado: (2021)

L-Asparaginase-Induced Pancreatic Injury is Associated with an Imbalance in Plasma Amino Acid Levels
por: Minowa, Kei, et al.
Publicado: (2012)

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice
por: Kumar, Gundala Venkata Naveen, et al.
Publicado: (2021)

Amino acid stress response genes promote L-asparaginase resistance in pediatric acute lymphoblastic leukemia
por: Ferguson, Daniel C., et al.
Publicado: (2022)

Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin
por: Park, Jinhee, et al.
Publicado: (2018)

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway
por: Butler, Miriam, et al.
Publicado: (2021)

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae
por: Zaborske, John M, et al.
Publicado: (2010)

SUPPRESSION OF MURINE LEUKEMIAS BY L-ASPARAGINASE : INCIDENCE OF SENSITIVITY AMONG LEUKEMIAS OF VARIOUS TYPES: COMPARATIVE INHIBITORY ACTIVITIES OF GUINEA PIG SERUML-ASPARAGINASE AND ESCHERICHIA COLI L-ASPARAGINASE
por: Boyse, Edward A., et al.
Publicado: (1967)

Allergic Reactions to E. coli Asparaginase are Associated with Decreased Asparaginase Activity in an Indonesian Pediatric Population with ALL
por: Sari, Nur Melani, et al.
Publicado: (2023)

Monitoring of asparagine depletion and anti-l-asparaginase antibodies in adult acute lymphoblastic leukemia treated in the pediatric-inspired GRAALL-2005 trial
por: Paillassa, Jérôme, et al.
Publicado: (2018)

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
por: Teske, Brian F., et al.
Publicado: (2011)

Kinetic proteomics identifies targeted changes in liver metabolism and the ribo-interactome by dietary sulfur amino acid restriction
por: Jonsson, William O., et al.
Publicado: (2023)

Exploration of the binding modes of l-asparaginase complexed with its amino acid substrates by molecular docking, dynamics and simulation
por: Reddy, Erva Rajeswara, et al.
Publicado: (2016)

Diabetes ketoacidosis in L-asparaginase therapy
por: Mabulac, Marichu P, et al.
Publicado: (2013)

Asparaginase: an old drug with new questions
por: Cecconello, Daiane Keller, et al.
Publicado: (2020)

Pharmacogenetics of asparaginase in acute lymphoblastic leukemia
por: Abaji, Rachid, et al.
Publicado: (2019)

Rates of protein synthesis are maintained in brain but reduced in skeletal muscle during dietary sulfur amino acid restriction
por: Martinez, Wenceslao, et al.
Publicado: (2022)

Metabolomic Response of Equine Skeletal Muscle to Acute Fatiguing Exercise and Training
por: Klein, Dylan J., et al.
Publicado: (2020)

The effects of nature‐inspired amino acid substitutions on structural and biochemical properties of the E. coli L‐asparaginase EcAIII
por: Janicki, Maciej, et al.
Publicado: (2023)

PEG-asparaginase and native Escherichia coli L-asparaginase in acute lymphoblastic leukemia in children and adolescents: a systematic review
por: Medawar, Camile Valle, et al.
Publicado: (2020)

HLA alleles associated with asparaginase hypersensitivity in Chinese children
por: Chua, Gilbert T., et al.
Publicado: (2021)

Sagittal sinus thrombosis due to L-asparaginase
por: Wani, Nisar A., et al.
Publicado: (2010)

Transient diabetes mellitus secondary to L-asparaginase
por: Matitu-Untalan, Lalaine Audrey G
Publicado: (2013)

Asparaginase pharmacokinetics and implications of therapeutic drug monitoring
por: Asselin, Barbara, et al.
Publicado: (2015)

Novel site-specific PEGylated L-asparaginase
por: Meneguetti, Giovanna Pastore, et al.
Publicado: (2019)

Diabetic ketoacidosis following PEG-asparaginase therapy
por: Ahmad, Miriam Hinaa, et al.
Publicado: (2018)

Recent Strategies and Applications for l-Asparaginase Confinement
por: Nunes, João C. F., et al.
Publicado: (2020)

Asparaginase: Sinus vein thrombosis: case report
Publicado: (2022)

Peg-Grafted Liposomes for L-Asparaginase Encapsulation
por: de Souza Guimarães, Marina, et al.
Publicado: (2022)

Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci
por: Zhu, Qiaoqiao, et al.
Publicado: (2019)

Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli‐Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia
por: Vrooman, Lynda M., et al.
Publicado: (2015)

Extracellular vesicles are independent metabolic units with asparaginase activity
por: Iraci, Nunzio, et al.
Publicado: (2017)

Acute myeloid leukaemia niche regulates response to L‐asparaginase
por: Kaspers, Gertjan J. L.
Publicado: (2019)

Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model
por: Liu, Chengcheng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ik6b7sicqnf9roua2ags00kkmp