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A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks

DNA damage response (DDR) is needed to repair damaged DNA for genomic integrity preservation. Defective DDR causes accumulation of deleterious mutations and DNA lesions that can lead to genomic instabilities and carcinogenesis. Identifying new players in the DDR, therefore, is essential to advance t...

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Detalles Bibliográficos
Autores principales: Abu-Zhayia, Enas R., Khoury-Haddad, Hanan, Guttmann-Raviv, Noga, Serruya, Raphael, Jarrous, Nayef, Ayoub, Nabieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430778/
https://www.ncbi.nlm.nih.gov/pubmed/28432356
http://dx.doi.org/10.1038/s41598-017-01185-6