Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer

Drug resistance remains an elusive problem in cancer therapy, particularly for novel targeted therapies. Much work is focused upon the development of an arsenal of targeted therapies, towards oncogenic driver genes such as ALK-EML4, to overcome the inevitable resistance that develops over time. Curr...

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Detalles Bibliográficos
Autores principales: Dhawan, Andrew, Nichol, Daniel, Kinose, Fumi, Abazeed, Mohamed E., Marusyk, Andriy, Haura, Eric B., Scott, Jacob G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430816/
https://www.ncbi.nlm.nih.gov/pubmed/28450729
http://dx.doi.org/10.1038/s41598-017-00791-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430816/
https://www.ncbi.nlm.nih.gov/pubmed/28450729
http://dx.doi.org/10.1038/s41598-017-00791-8

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