RRM domain of ALS/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils

526-residue FUS functions to self-assemble into reversible droplets/hydrogels, which could be further solidified into pathological fibrils. FUS is intrinsically prone to aggregation, composed of N-terminal low-sequence complexity (LC); RNA-recognition motif (RRM) and C-terminal LC domains. Intriguin...

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Detalles Bibliográficos
Autores principales: Lu, Yimei, Lim, Liangzhong, Song, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430844/
https://www.ncbi.nlm.nih.gov/pubmed/28432364
http://dx.doi.org/10.1038/s41598-017-01281-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430844/
https://www.ncbi.nlm.nih.gov/pubmed/28432364
http://dx.doi.org/10.1038/s41598-017-01281-7

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