A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines

Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the hu...

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Detalles Bibliográficos
Autores principales: Wada, Yamato, Nithichanon, Arnone, Nobusawa, Eri, Moise, Leonard, Martin, William D., Yamamoto, Norio, Terahara, Kazutaka, Hagiwara, Haruhisa, Odagiri, Takato, Tashiro, Masato, Lertmemongkolchai, Ganjana, Takeyama, Haruko, De Groot, Anne S., Ato, Manabu, Takahashi, Yoshimasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430863/
https://www.ncbi.nlm.nih.gov/pubmed/28455520
http://dx.doi.org/10.1038/s41598-017-01372-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430863/
https://www.ncbi.nlm.nih.gov/pubmed/28455520
http://dx.doi.org/10.1038/s41598-017-01372-5

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