Cargando…
Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts
Recent therapeutic approaches of rheumatoid arthritis (RA) address the use of small molecules such as tyrosine kinase inhibitors (TKIs). However, the TKIs developed to date have important side effects and/or scarce efficacy in inflammatory diseases such as RA. Since intracellular effective TKIs must...
Autores principales: | Harrach, Saliha, Edemir, Bayram, Schmidt-Lauber, Christian, Pap, Thomas, Bertrand, Jessica, Ciarimboli, Giuliano |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430895/ https://www.ncbi.nlm.nih.gov/pubmed/28455521 http://dx.doi.org/10.1038/s41598-017-01438-4 |
Ejemplares similares
-
Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis
por: Schmidt-Lauber, Christian, et al.
Publicado: (2012) -
Activation of Synovial Fibroblasts in Rheumatoid Arthritis
por: Gay, Steffen, et al.
Publicado: (2000) -
Interaction of Masitinib with Organic Cation Transporters
por: Harrach, Saliha, et al.
Publicado: (2022) -
Cells of the synovium in rheumatoid arthritis. Synovial fibroblasts
por: Müller-Ladner, Ulf, et al.
Publicado: (2007) -
Fibroblast biology: Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis
por: Pap, Thomas, et al.
Publicado: (2000)