Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin

Thrombin is a multifunctional enzyme with a key role in the coagulation cascade. Its functional modulation can culminate into normal blood coagulation or thrombosis. Thus, the identification of novel potent inhibitors of thrombin are of immense importance. Sculptin is the first specific thrombin inh...

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Detalles Bibliográficos
Autores principales: Iqbal, Asif, Goldfeder, Mauricio Barbugiani, Marques-Porto, Rafael, Asif, Huma, Souza, Jean Gabriel de, Faria, Fernanda, Chudzinski-Tavassi, Ana Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431157/
https://www.ncbi.nlm.nih.gov/pubmed/28469161
http://dx.doi.org/10.1038/s41598-017-01486-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431157/
https://www.ncbi.nlm.nih.gov/pubmed/28469161
http://dx.doi.org/10.1038/s41598-017-01486-w

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