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Allosteric conformational changes of human HBV core protein transform its assembly

Hepatitis B Virus core protein (HBc) has multiple roles in the viral lifecycle: viral assembly, compartment for reverse transcription, intracellular trafficking, and nuclear functions. HBc displays assembly polymorphism - it can assemble into icosahedral capsid and aberrant non-capsid structures. It...

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Detalles Bibliográficos
Autores principales: Liu, Chuang, Fan, Guizhen, Wang, Zhao, Chen, Hong-Song, Yin, Chang-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431180/
https://www.ncbi.nlm.nih.gov/pubmed/28469174
http://dx.doi.org/10.1038/s41598-017-01568-9