Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice

In striated muscle, desmin intermediate filaments interlink the contractile myofibrillar apparatus with mitochondria, nuclei, and the sarcolemma. The desmin network’s pivotal role in myocytes is evident since mutations in the human desmin gene cause severe myopathies and cardiomyopathies. Here, we i...

Descripción completa

Detalles Bibliográficos
Autores principales: Diermeier, Stefanie, Iberl, Julian, Vetter, Kristina, Haug, Michael, Pollmann, Charlotte, Reischl, Barbara, Buttgereit, Andreas, Schürmann, Sebastian, Spörrer, Marina, Goldmann, Wolfgang H., Fabry, Ben, Elhamine, Fatiha, Stehle, Robert, Pfitzer, Gabriele, Winter, Lilli, Clemen, Christoph S., Herrmann, Harald, Schröder, Rolf, Friedrich, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431221/
https://www.ncbi.nlm.nih.gov/pubmed/28469177
http://dx.doi.org/10.1038/s41598-017-01485-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431221/
https://www.ncbi.nlm.nih.gov/pubmed/28469177
http://dx.doi.org/10.1038/s41598-017-01485-x

Ejemplares similares