Low-basicity 5-HT(7) Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol

A series of 5-aryl-1-alkylimidazole derivatives was synthesized using the van Leusen multicomponent reaction. The chemotype is the first example of low-basicity scaffolds exhibiting high affinity for 5-HT(7) receptor together with agonist function. The chosen lead compounds 3-(1-ethyl-1H-imidazol-5-...

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Detalles Bibliográficos
Autores principales: Hogendorf, Adam S., Hogendorf, Agata, Kurczab, Rafał, Satała, Grzegorz, Lenda, Tomasz, Walczak, Maria, Latacz, Gniewomir, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna, Wierońska, Joanna M., Woźniak, Monika, Cieślik, Paulina, Bugno, Ryszard, Staroń, Jakub, Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431432/
https://www.ncbi.nlm.nih.gov/pubmed/28473721
http://dx.doi.org/10.1038/s41598-017-00822-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431432/
https://www.ncbi.nlm.nih.gov/pubmed/28473721
http://dx.doi.org/10.1038/s41598-017-00822-4

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