Cargando…

Low-basicity 5-HT(7) Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol

A series of 5-aryl-1-alkylimidazole derivatives was synthesized using the van Leusen multicomponent reaction. The chemotype is the first example of low-basicity scaffolds exhibiting high affinity for 5-HT(7) receptor together with agonist function. The chosen lead compounds 3-(1-ethyl-1H-imidazol-5-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hogendorf, Adam S., Hogendorf, Agata, Kurczab, Rafał, Satała, Grzegorz, Lenda, Tomasz, Walczak, Maria, Latacz, Gniewomir, Handzlik, Jadwiga, Kieć-Kononowicz, Katarzyna, Wierońska, Joanna M., Woźniak, Monika, Cieślik, Paulina, Bugno, Ryszard, Staroń, Jakub, Bojarski, Andrzej J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431432/ https://www.ncbi.nlm.nih.gov/pubmed/28473721 http://dx.doi.org/10.1038/s41598-017-00822-4

Ejemplares similares

N-Skatyltryptamines—Dual 5-HT(6)R/D(2)R Ligands with Antipsychotic and Procognitive Potential
por: Hogendorf, Agata, et al.
Publicado: (2021)

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT(6) Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo
por: Kurczab, Rafał, et al.
Publicado: (2018)

The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT(6) receptor antagonists and beyond
por: Kalinowska-Tłuścik, Justyna, et al.
Publicado: (2018)

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT(6) Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment
por: Latacz, Gniewomir, et al.
Publicado: (2019)

Are the Hydantoin-1,3,5-triazine 5-HT(6)R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro
por: Lubelska, Annamaria, et al.
Publicado: (2019)

The Stereoselectivity and Hydrolysis Efficiency of Recombinant d-Hydantoinase from Vigna angularis Against 5-Benzylhydantoin Derivatives with Halogen and Methyl Substituents
por: Latacz, Gniewomir, et al.
Publicado: (2014)

New Triazine Derivatives as Serotonin 5-HT(6) Receptor Ligands
por: Łażewska, Dorota, et al.
Publicado: (2023)

Study on the effect of EMD386088, a 5-HT(6) receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats
por: Jastrzębska-Więsek, Magdalena, et al.
Publicado: (2017)

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2
por: Podlewska, Sabina, et al.
Publicado: (2021)

Synthesis of Imidazole-Based Medicinal Molecules Utilizing the van Leusen Imidazole Synthesis
por: Zheng, Xunan, et al.
Publicado: (2020)

Phenylpiperazine 5,5-Dimethylhydantoin Derivatives as First Synthetic Inhibitors of Msr(A) Efflux Pump in Staphylococcus epidermidis
por: Witek, Karolina, et al.
Publicado: (2020)

Allosteric Inhibition of Serotonin 5-HT(7) Receptors by Zinc Ions
por: Satała, Grzegorz, et al.
Publicado: (2017)

Recent Advances in the Synthesis of Oxazole-Based Molecules via van Leusen Oxazole Synthesis
por: Zheng, Xunan, et al.
Publicado: (2020)

Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu(7) Receptor Modulation Activity and Antipsychotic-Like Properties
por: Kaczorowska, Katarzyna, et al.
Publicado: (2023)

Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats
por: Alachkar, Alaa, et al.
Publicado: (2018)

Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design
por: Castellucci Estevam, Ethiene, et al.
Publicado: (2015)

New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT(1A)/5-HT(7) Affinity and Its Antidepressant-like Activity
por: Zaręba, Przemysław, et al.
Publicado: (2022)

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus
por: Handzlik, Jadwiga, et al.
Publicado: (2013)

The Phenoxyalkyltriazine Antagonists for 5-HT(6) Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases
por: Sudoł, Sylwia, et al.
Publicado: (2021)

Selenazolinium Salts as “Small Molecule Catalysts” with High Potency against ESKAPE Bacterial Pathogens
por: Witek, Karolina, et al.
Publicado: (2017)

5-Arylideneimidazolones with Amine at Position 3 as Potential Antibiotic Adjuvants against Multidrug Resistant Bacteria
por: Kaczor, Aneta, et al.
Publicado: (2019)

Histamine H(3) Receptor Ligands—KSK-59 and KSK-73—Reduce Body Weight Gain in a Rat Model of Excessive Eating
por: Mika, Kamil, et al.
Publicado: (2021)

2-Phenyl-1H-pyrrole-3-carboxamide as a New Scaffold for Developing 5-HT(6) Receptor Inverse Agonists with Cognition-Enhancing Activity
por: Drop, Marcin, et al.
Publicado: (2021)

Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT(1A), 5-HT(7), and D(2) receptor ligands
por: Marciniec, Krzysztof, et al.
Publicado: (2018)

The Structural Determinants for α(1)-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives
por: Kucwaj-Brysz, Katarzyna, et al.
Publicado: (2021)

Salsolinol—neurotoxic or Neuroprotective?
por: Kurnik-Łucka, Magdalena, et al.
Publicado: (2019)

Structure Prediction, Evaluation, and Validation of GPR18 Lipid Receptor Using Free Programs
por: Michalik, Ilona, et al.
Publicado: (2022)

Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT(7) Receptor
por: Kułaga, Damian, et al.
Publicado: (2022)

Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT(3) and 5-HT(6) Receptor Antagonist with Antipsychotic and Procognitive Properties
por: Zajdel, Paweł, et al.
Publicado: (2021)

An Algorithm to Identify Target-Selective Ligands – A Case Study of 5-HT7/5-HT1A Receptor Selectivity
por: Kurczab, Rafał, et al.
Publicado: (2016)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
por: Sadek, Bassem, et al.
Publicado: (2016)

Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance
por: Kaczor, Aneta, et al.
Publicado: (2020)

Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity
por: Marć, Małgorzata Anna, et al.
Publicado: (2022)

Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity
por: Tejchman, Waldemar, et al.
Publicado: (2019)

Spiro[pyrrolidine-3,3′-oxindoles] and Their Indoline Analogues as New 5-HT6 Receptor Chemotypes
por: Kelemen, Ádám A., et al.
Publicado: (2017)

Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies
por: Satała, Grzegorz, et al.
Publicado: (2015)

Design, synthesis and photophysical properties of novel star-shaped truxene-based heterocycles utilizing ring-closing metathesis, Clauson–Kaas, Van Leusen and Ullmann-type reactions as key tools
por: Alvi, Shakeel, et al.
Publicado: (2021)

Superiority of the Triple-Acting 5-HT(6)R/5-HT(3)R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT(6)R Antagonist Intepirdine in Alleviation of Cognitive Deficits in Rats
por: Grychowska, Katarzyna, et al.
Publicado: (2023)

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H(3) Receptor Antagonists and Monoamine Oxidase B Inhibitors
por: Łażewska, Dorota, et al.
Publicado: (2020)

Trisubstituted 1,3,5-Triazines as Histamine H(4) Receptor Antagonists with Promising Activity In Vivo
por: Olejarz-Maciej, Agnieszka, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5rknnefhiauijn0pqm2423g63n