Structure aided design of a Neu5Gc specific lectin

Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells. Elevated Neu5Gc...

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Detalles Bibliográficos
Autores principales: Day, Christopher J., Paton, Adrienne W., Higgins, Melanie A., Shewell, Lucy K., Jen, Freda E.-C., Schulz, Benjamin L., Herdman, Brock P., Paton, James C., Jennings, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431456/
https://www.ncbi.nlm.nih.gov/pubmed/28473713
http://dx.doi.org/10.1038/s41598-017-01522-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431456/
https://www.ncbi.nlm.nih.gov/pubmed/28473713
http://dx.doi.org/10.1038/s41598-017-01522-9

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