Cargando…

Structure aided design of a Neu5Gc specific lectin

Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2–3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells. Elevated Neu5Gc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Day, Christopher J., Paton, Adrienne W., Higgins, Melanie A., Shewell, Lucy K., Jen, Freda E.-C., Schulz, Benjamin L., Herdman, Brock P., Paton, James C., Jennings, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431456/ https://www.ncbi.nlm.nih.gov/pubmed/28473713 http://dx.doi.org/10.1038/s41598-017-01522-9

Ejemplares similares

Lectin activity of the pneumococcal pilin proteins
por: Day, Christopher J., et al.
Publicado: (2017)

Refinement of immunizing antigens to produce functional blocking antibodies against the AniA nitrite reductase of Neisseria gonorrhoeae
por: Shewell, Lucy K., et al.
Publicado: (2017)

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans
por: Gao, Bingsi, et al.
Publicado: (2017)

Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans—An Evolutionary Perspective
por: Altman, Meghan O., et al.
Publicado: (2019)

N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease
por: Shewell, Lucy K., et al.
Publicado: (2022)

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors
por: Ng, Preston S.K., et al.
Publicado: (2014)

At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody
por: Yu, Chuanfei, et al.
Publicado: (2016)

N-Glycolylneuraminic Acid (Neu5Gc) Null Large Animals by Targeting the CMP-Neu5Gc Hydroxylase (CMAH)
por: Perota, Andrea, et al.
Publicado: (2019)

All major cholesterol-dependent cytolysins use glycans as cellular receptors
por: Shewell, Lucy K., et al.
Publicado: (2020)

Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids
por: Nemanichvili, Nikoloz, et al.
Publicado: (2022)

Erratum: At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody
por: Yu, Chuanfei, et al.
Publicado: (2017)

The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates
por: Mahdi, Layla K., et al.
Publicado: (2017)

Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS
por: Boligan, Kayluz F., et al.
Publicado: (2020)

N-glycolylneuraminic acid as a carbohydrate cancer biomarker
por: Wang, Jing, et al.
Publicado: (2023)

Prevalence of Anti-Neu5Gc Antibodies in Patients with Hypothyroidism
por: Eleftheriou, Phaedra, et al.
Publicado: (2014)

The Possible Role of Anti-Neu5Gc as an Obstacle in Xenotransplantation
por: Tector, Alfred Joseph, et al.
Publicado: (2020)

Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides
por: Kooner, Anoopjit Singh, et al.
Publicado: (2019)

Phylogenetic Distribution of CMP-Neu5Ac Hydroxylase (CMAH), the Enzyme Synthetizing the Proinflammatory Human Xenoantigen Neu5Gc
por: Peri, Sateesh, et al.
Publicado: (2017)

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera
por: Alisson-Silva, Frederico, et al.
Publicado: (2018)

Repurposing Carbamazepine To Treat Gonococcal Infection in Women: Oral Delivery for Control of Epilepsy Generates Therapeutically Effective Levels in Vaginal Secretions
por: Shewell, Lucy K., et al.
Publicado: (2023)

Escherichia coli Subtilase Cytotoxin
por: Paton, Adrienne W., et al.
Publicado: (2010)

Theoretical Studies on the Electronic Structure Parameters and Reactive Activity of Neu5Gc and Neu5Ac under Food Processing Solvent Environment
por: Chang, Rui, et al.
Publicado: (2019)

Challenging the Role of Diet-Induced Anti-Neu5Gc Antibodies in Human Pathologies
por: Soulillou, Jean-Paul, et al.
Publicado: (2020)

CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans
por: Kwon, Deug-Nam, et al.
Publicado: (2015)

A Simple Method for Assessment of Human Anti-Neu5Gc Antibodies Applied to Kawasaki Disease
por: Padler-Karavani, Vered, et al.
Publicado: (2013)

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages
por: Johnson, Nicholas, et al.
Publicado: (2013)

Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response
por: Frei, Remo, et al.
Publicado: (2019)

P3 mAb: An Immunogenic Anti-NeuGcGM3 Antibody with Unusual Immunoregulatory Properties
por: Martínez, Darel, et al.
Publicado: (2012)

Frequent co-expression of EGFR and NeuGcGM3 ganglioside in cancer: it’s potential therapeutic implications
por: Palomo, Addys González, et al.
Publicado: (2016)

Prognostic Significance of Tumor Tissue NeuGcGM3 Ganglioside Expression in Patients Receiving Racotumomab Immunotherapy
por: Uskent, Necdet, et al.
Publicado: (2020)

High-Frequency Changes in Pilin Glycosylation Patterns during Neisseria meningitidis Serogroup a Meningitis Outbreaks in the African Meningitis Belt
por: Jen, Freda E.-C., et al.
Publicado: (2023)

A New Family of Potent AB(5) Cytotoxins Produced by Shiga Toxigenic Escherichia coli
por: Paton, Adrienne W., et al.
Publicado: (2004)

Correction
por: Paton, Adrienne W., et al.
Publicado: (2004)

Preconditioning with Endoplasmic Reticulum Stress Ameliorates Endothelial Cell Inflammation
por: Leonard, Antony, et al.
Publicado: (2014)

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier
por: Haßdenteufel, Sarah, et al.
Publicado: (2018)

Anti-ganglioside antibodies induced in chickens by an alum-adsorbed anti-idiotype antibody targeting NeuGcGM3
por: Guthmann, Marcelo D., et al.
Publicado: (2013)

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
por: Dhar, Chirag, et al.
Publicado: (2019)

Editorial: Human Antibodies Against the Dietary Non-human Neu5Gc-Carrying Glycans in Normal and Pathologic States
por: Soulillou, Jean-Paul, et al.
Publicado: (2020)

Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome
por: Hostetter, Shannon J, et al.
Publicado: (2014)

The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate
por: Jen, Freda E.-C., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2gu48t0mjsi41fs2ga5i6rsssp