Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer

Endoplasmic reticulum (ER) stress initiates an important mechanism for cell adaptation and survival, named the unfolded protein response (UPR). Severe or chronic/prolonged UPR can breach the threshold for survival and lead to cell death. There is a fundamental gap in knowledge on the molecular mecha...

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Detalles Bibliográficos
Autores principales: Dauer, Patricia, Gupta, Vineet K., McGinn, Olivia, Nomura, Alice, Sharma, Nikita S., Arora, Nivedita, Giri, Bhuwan, Dudeja, Vikas, Saluja, Ashok K., Banerjee, Sulagna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431512/
https://www.ncbi.nlm.nih.gov/pubmed/28484232
http://dx.doi.org/10.1038/s41598-017-01696-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431512/
https://www.ncbi.nlm.nih.gov/pubmed/28484232
http://dx.doi.org/10.1038/s41598-017-01696-2

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