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siRNA-mediated knockdown of ID1 disrupts Nanog- and Oct-4-mediated cancer stem cell-likeness and resistance to chemotherapy in gastric cancer cells

DNA-binding protein inhibitor ID-1 (ID1) serves an essential role in tumor progression, and the self-renewal and pluripotency of embryonic stem cells. However, the effect of ID1 on the stemness and cancer stem cell (CSC)-like properties of gastric adenocarcinoma cells remains to be elucidated. In th...

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Detalles Bibliográficos
Autores principales: Li, Linlin, Wei, Xiaoyong, Wu, Baofeng, Xiao, Yuanli, Yin, Mingzhu, Yang, Qiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431526/
https://www.ncbi.nlm.nih.gov/pubmed/28529558
http://dx.doi.org/10.3892/ol.2017.5828