Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib

Small molecules targeting the EGFR tyrosine kinase domain have been used with some success at treating patients with non-small cell lung cancer driven by activating mutations in the kinase domain. The initial class of inhibitors displaced ATP noncovalently but were rendered ineffective due to the de...

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Detalles Bibliográficos
Autores principales: Kannan, Srinivasaraghavan, Pradhan, Mohan R., Tiwari, Garima, Tan, Wei-Chong, Chowbay, Balram, Tan, Eng Huat, Tan, Daniel Shao-Weng, Verma, Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431542/
https://www.ncbi.nlm.nih.gov/pubmed/28484248
http://dx.doi.org/10.1038/s41598-017-01491-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431542/
https://www.ncbi.nlm.nih.gov/pubmed/28484248
http://dx.doi.org/10.1038/s41598-017-01491-z

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