Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis

One of the key limitations to successful human islet transplantation is loss of islets due to stress responses pre- and post-transplantation. Nutrient deprivation and ER stress have been identified as important mechanisms leading to apoptosis. Glial Cell-line Derived Neurotrophic Factor (GDNF) has r...

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Detalles Bibliográficos
Autores principales: Abadpour, Shadab, Göpel, Sven O., Schive, Simen W., Korsgren, Olle, Foss, Aksel, Scholz, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431546/
https://www.ncbi.nlm.nih.gov/pubmed/28484241
http://dx.doi.org/10.1038/s41598-017-01805-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431546/
https://www.ncbi.nlm.nih.gov/pubmed/28484241
http://dx.doi.org/10.1038/s41598-017-01805-1

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