Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase

The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 Å) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety...

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Detalles Bibliográficos
Autores principales: Jain, Rinku, Butler, Kyle V., Coloma, Javier, Jin, Jian, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431627/
https://www.ncbi.nlm.nih.gov/pubmed/28487506
http://dx.doi.org/10.1038/s41598-017-01756-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431627/
https://www.ncbi.nlm.nih.gov/pubmed/28487506
http://dx.doi.org/10.1038/s41598-017-01756-7

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