Mapping a protein recognition centre with chiral photoactive ligands. An integrated approach combining photophysics, reactivity, proteomics and molecular dynamics simulation studies

A multidisciplinary strategy to obtain structural information on the intraprotein region is described here. As probe ligands, (S)- and (R)-CPFMe (the methyl esters of the chiral drug carprofen) have been selected, while bovine α(1)-acid glycoprotein (BAAG) has been chosen as a biological host. The p...

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Detalles Bibliográficos
Autores principales: Limones-Herrero, Daniel, Pérez-Ruiz, Raúl, Lence, Emilio, González-Bello, Concepción, Miranda, Miguel A., Jiménez, M. Consuelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431658/
https://www.ncbi.nlm.nih.gov/pubmed/28553497
http://dx.doi.org/10.1039/c6sc04900a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431658/
https://www.ncbi.nlm.nih.gov/pubmed/28553497
http://dx.doi.org/10.1039/c6sc04900a

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