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In vivo and in vitro ageing results in accumulation of de novo copy number variations in bulls

We have identified de novo copy number variations (CNVs) generated in bulls as they age. Blood samples from eight bulls were collected and SNP arrayed in a prospective design over 30 months allowing us to differentiate de novo CNVs from constant CNVs that are present throughout the sampling period....

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Detalles Bibliográficos
Autores principales: Revay, Tamas, Oluwole, Olutobi, Kroetsch, Tom, King, W. Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431667/
https://www.ncbi.nlm.nih.gov/pubmed/28487564
http://dx.doi.org/10.1038/s41598-017-01793-2