Common sequence variants affect molecular function more than rare variants?

Any two unrelated individuals differ by about 10,000 single amino acid variants (SAVs). Do these impact molecular function? Experimental answers cannot answer comprehensively, while state-of-the-art prediction methods can. We predicted the functional impacts of SAVs within human and for variants bet...

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Detalles Bibliográficos
Autores principales: Mahlich, Yannick, Reeb, Jonas, Hecht, Maximilian, Schelling, Maria, De Beer, Tjaart Andries Petrus, Bromberg, Yana, Rost, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431670/
https://www.ncbi.nlm.nih.gov/pubmed/28487536
http://dx.doi.org/10.1038/s41598-017-01054-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431670/
https://www.ncbi.nlm.nih.gov/pubmed/28487536
http://dx.doi.org/10.1038/s41598-017-01054-2

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