Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Hedgehog (Hh) pathway is involved in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) maintenance resulting in tumor progression. GDC-0449, an inhibitor of Hh pathway component smoothened (Smo) has shown promise in the treatment of various cancers including pancreatic cancer. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Vinod, Chaudhary, Amit Kumar, Dong, Yuxiang, Zhong, Haizhen A., Mondal, Goutam, Lin, Feng, Kumar, Virender, Mahato, Ram I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431907/
https://www.ncbi.nlm.nih.gov/pubmed/28490735
http://dx.doi.org/10.1038/s41598-017-01942-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431907/
https://www.ncbi.nlm.nih.gov/pubmed/28490735
http://dx.doi.org/10.1038/s41598-017-01942-7

Ejemplares similares