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Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model

Alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists can prevent glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs). However, the neuroprotective effects and the mechanism of action of PNU-282987, an α7-nAChR agonist, in a chronic in vivo rat glaucoma model are poorly...

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Detalles Bibliográficos
Autores principales:	Zhou, Xujiao, Cheng, Yun, Zhang, Rong, Li, Gang, Yang, Boqi, Zhang, Shenghai, Wu, Jihong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431927/ https://www.ncbi.nlm.nih.gov/pubmed/28496108 http://dx.doi.org/10.1038/s41598-017-02092-6

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