Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

The penicillinase-resistant antibiotics (PRAs), especially the highly prescribed flucloxacillin, caused frequent liver injury via mechanisms that remain largely non-elucidated. We first showed that flucloxacillin, independently of cytotoxicity, could exhibit cholestatic effects in human hepatocytes...

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Detalles Bibliográficos
Autores principales: Burban, Audrey, Sharanek, Ahmad, Hüe, Romain, Gay, Marion, Routier, Sylvain, Guillouzo, André, Guguen-Guillouzo, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431934/
https://www.ncbi.nlm.nih.gov/pubmed/28500348
http://dx.doi.org/10.1038/s41598-017-01171-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431934/
https://www.ncbi.nlm.nih.gov/pubmed/28500348
http://dx.doi.org/10.1038/s41598-017-01171-y

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