Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

We previously reported that activation of the host autophagic protein, Beclin1, by HIV-1 infection represents an essential mechanism in controlling HIV replication and viral-induced inflammatory responses in microglial cells. Existing antiretroviral therapeutic approaches have been limited in their...

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Detalles Bibliográficos
Autores principales: Rodriguez, Myosotys, Lapierre, Jessica, Ojha, Chet Raj, Kaushik, Ajeet, Batrakova, Elena, Kashanchi, Fatah, Dever, Seth M., Nair, Madhavan, El-Hage, Nazira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431946/
https://www.ncbi.nlm.nih.gov/pubmed/28500326
http://dx.doi.org/10.1038/s41598-017-01819-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431946/
https://www.ncbi.nlm.nih.gov/pubmed/28500326
http://dx.doi.org/10.1038/s41598-017-01819-9

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