Cargando…

Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

We previously reported that activation of the host autophagic protein, Beclin1, by HIV-1 infection represents an essential mechanism in controlling HIV replication and viral-induced inflammatory responses in microglial cells. Existing antiretroviral therapeutic approaches have been limited in their...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodriguez, Myosotys, Lapierre, Jessica, Ojha, Chet Raj, Kaushik, Ajeet, Batrakova, Elena, Kashanchi, Fatah, Dever, Seth M., Nair, Madhavan, El-Hage, Nazira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431946/ https://www.ncbi.nlm.nih.gov/pubmed/28500326 http://dx.doi.org/10.1038/s41598-017-01819-9

Ejemplares similares

Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
por: Rodriguez, Myosotys, et al.
Publicado: (2018)

Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy
por: Karuppan, Mohan Kumar Muthu, et al.
Publicado: (2020)

Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles
por: Rodriguez, Myosotys, et al.
Publicado: (2021)

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes
por: Rodriguez, Myosotys, et al.
Publicado: (2017)

Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes
por: Ojha, Chet Raj, et al.
Publicado: (2019)

Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications
por: Ojha, Chet Raj, et al.
Publicado: (2017)

Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus
por: Ojha, Chet Raj, et al.
Publicado: (2018)

Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections
por: Ojha, Chet Raj, et al.
Publicado: (2016)

Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses
por: Rodriguez, Myosotys, et al.
Publicado: (2023)

Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure
por: Dever, Seth M., et al.
Publicado: (2015)

Linear and Branched PEIs (Polyethylenimines) and Their Property Space
por: Lungu, Claudiu N., et al.
Publicado: (2016)

Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time
por: Pleet, Michelle L., et al.
Publicado: (2018)

Polyethylenimine (PEI)-Mediated E1A Increases the Sensitivity of Hepatocellular Carcinoma Cells to Chemotherapy
por: Li, Zhanfeng, et al.
Publicado: (2019)

Cellulose Modified with Polyethylenimine (PEI) Using Microwave Methodology for Adsorption of Chromium from Aqueous Solutions
por: Pattarith, Kongsak, et al.
Publicado: (2023)

Differential intracellular distribution of DNA complexed with polyethylenimine (PEI) and PEI-polyarginine PTD influences exogenous gene expression within live COS-7 cells
por: Doyle, Stephen R, et al.
Publicado: (2007)

Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease
por: El-Hage, Nazira, et al.
Publicado: (2023)

Role of Four Different Kinds of Polyethylenimines (PEIs) in Preparation of Polymeric Lipid Nanoparticles and Their Anticancer Activity Study
por: Yu, Kongtong, et al.
Publicado: (2016)

Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown
por: Noske, Sandra, et al.
Publicado: (2020)

Two Antibody-Guided Lactic-co-Glycolic Acid-Polyethylenimine (LGA-PEI) Nanoparticle Delivery Systems for Therapeutic Nucleic Acids
por: Lü, Jian-Ming, et al.
Publicado: (2021)

Delivery of small interfering RNAs in human cervical cancer cells by polyethylenimine-functionalized carbon nanotubes
por: Huang, Yuan-Pin, et al.
Publicado: (2013)

CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC
por: Liu, Wangta, et al.
Publicado: (2019)

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration
por: Rodriguez, Myosotys, et al.
Publicado: (2020)

Suppression of Breast Cancer Cell Migration by Small Interfering RNA Delivered by Polyethylenimine-Functionalized Graphene Oxide
por: Huang, Yuan-Pin, et al.
Publicado: (2016)

SERPIN-Derived Small Peptide (SP16) as a Potential Therapeutic Agent against HIV-Induced Inflammatory Molecules and Viral Replication in Cells of the Central Nervous System
por: Soler, Yemmy, et al.
Publicado: (2023)

Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair
por: Branscome, Heather, et al.
Publicado: (2020)

Using Extracellular Vesicles Released by GDNF-Transfected Macrophages for Therapy of Parkinson Disease
por: Zhao, Yuling, et al.
Publicado: (2022)

The Immunoenhancement Effects of Polyethylenimine-Modified Chinese Yam Polysaccharide-Encapsulated PLGA Nanoparticles as an Adjuvant
por: Zhang, Yue, et al.
Publicado: (2020)

Branched Polyethylenimine-Superparamagnetic Iron Oxide Nanoparticles (bPEI-SPIONs) Improve the Immunogenicity of Tumor Antigens and Enhance Th1 Polarization of Dendritic Cells
por: Hoang, My-Dung, et al.
Publicado: (2015)

The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy
por: Caobi, Allen, et al.
Publicado: (2020)

Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains
por: Dong, Chunhong, et al.
Publicado: (2021)

Coaxial Synthesis of PEI-Based Nanocarriers of Encapsulated RNA-Therapeutics to Specifically Target Muscle Cells
por: de la Hoz, Raquel, et al.
Publicado: (2022)

Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells
por: Chen, Xiao-Ai, et al.
Publicado: (2011)

Two Major Archaeal Pseudomurein Endoisopeptidases: PeiW and PeiP
por: Visweswaran, Ganesh Ram R., et al.
Publicado: (2010)

Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers
por: Kaushik, Ajeet, et al.
Publicado: (2016)

Development of small interfering RNA delivery system using PEI-PEG-APRPG polymer for antiangiogenic vascular endothelial growth factor tumor-targeted therapy
por: Lu, Zong-Xia, et al.
Publicado: (2011)

Intranasal immunization with plasmid DNA encoding spike protein of SARS-coronavirus/polyethylenimine nanoparticles elicits antigen-specific humoral and cellular immune responses
por: Shim, Byoung-Shik, et al.
Publicado: (2010)

Biochemical Characterisation of Phage Pseudomurein Endoisopeptidases PeiW and PeiP Using Synthetic Peptides
por: Schofield, Linley R., et al.
Publicado: (2015)

Retroviral infection of human neurospheres and use of stem Cell EVs to repair cellular damage
por: Branscome, Heather, et al.
Publicado: (2022)

Targeting HPV‐infected cervical cancer cells with PEGylated liposomes encapsulating siRNA and the role of siRNA complexation with polyethylenimine
por: Levine, Rachel M., et al.
Publicado: (2016)

I. M. Pei : a profile in american architecture
por: Wiseman, Carter
Publicado: (1990)

Cannot write session to /tmp/vufind_sessions/sess_or56erejbh4vceehff2elpk4g9