Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protei...

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Autores principales: Arakelyan, Anush, Fitzgerald, Wendy, Zicari, Sonia, Vanpouille, Christophe, Margolis, Leonid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431974/
https://www.ncbi.nlm.nih.gov/pubmed/28490736
http://dx.doi.org/10.1038/s41598-017-01739-8
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author Arakelyan, Anush
Fitzgerald, Wendy
Zicari, Sonia
Vanpouille, Christophe
Margolis, Leonid
author_facet Arakelyan, Anush
Fitzgerald, Wendy
Zicari, Sonia
Vanpouille, Christophe
Margolis, Leonid
author_sort Arakelyan, Anush
collection PubMed
description Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy.
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spelling pubmed-54319742017-05-16 Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue Arakelyan, Anush Fitzgerald, Wendy Zicari, Sonia Vanpouille, Christophe Margolis, Leonid Sci Rep Article Cells productively infected with HIV-1 release virions along with extracellular vesicles (EVs) whose biogenesis, size, and physical properties resemble those of retroviruses. Here, we found that a significant number of EVs (exosomes) released by HIV-1 infected cells carry gp120 (Env), a viral protein that mediates virus attachment and fusion to target cells, and also facilitates HIV infection in various indirect ways. Depletion of viral preparations of EVs, in particular of those that carry gp120, decreases viral infection of human lymphoid tissue ex vivo. Thus, EVs that carry Env identified in our work seem to facilitate HIV infection and therefore may constitute a new therapeutic target for antiviral strategy. Nature Publishing Group UK 2017-05-10 /pmc/articles/PMC5431974/ /pubmed/28490736 http://dx.doi.org/10.1038/s41598-017-01739-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Arakelyan, Anush
Fitzgerald, Wendy
Zicari, Sonia
Vanpouille, Christophe
Margolis, Leonid
Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_full Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_fullStr Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_full_unstemmed Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_short Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue
title_sort extracellular vesicles carry hiv env and facilitate hiv infection of human lymphoid tissue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431974/
https://www.ncbi.nlm.nih.gov/pubmed/28490736
http://dx.doi.org/10.1038/s41598-017-01739-8
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