Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase

C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase. Each CHIP monomer consists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain. In contrast to nearly all homodimeric proteins, CHIP is asymmetric. To uncover the origins of asymmetry, we...

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Detalles Bibliográficos
Autores principales: Ye, Zhaofeng, Needham, Patrick G., Estabrooks, Samuel K., Whitaker, Susan K., Garcia, Brandon L., Misra, Saurav, Brodsky, Jeffrey L., Camacho, Carlos J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431976/
https://www.ncbi.nlm.nih.gov/pubmed/28496195
http://dx.doi.org/10.1038/s41598-017-01880-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431976/
https://www.ncbi.nlm.nih.gov/pubmed/28496195
http://dx.doi.org/10.1038/s41598-017-01880-4

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