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Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase
C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase. Each CHIP monomer consists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain. In contrast to nearly all homodimeric proteins, CHIP is asymmetric. To uncover the origins of asymmetry, we...
Autores principales: | Ye, Zhaofeng, Needham, Patrick G., Estabrooks, Samuel K., Whitaker, Susan K., Garcia, Brandon L., Misra, Saurav, Brodsky, Jeffrey L., Camacho, Carlos J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431976/ https://www.ncbi.nlm.nih.gov/pubmed/28496195 http://dx.doi.org/10.1038/s41598-017-01880-4 |
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