Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells

PURPOSE: We have shown previously that non-enzymatic nitration (NEN) of the extracellular matrix (ECM), which serves as a model of Bruch’s membrane (BM) aging, has a profound effect on the behavior of the overlying retinal pigment epithelial (RPE) cells, including altered phagocytic ability, reduced...

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Detalles Bibliográficos
Autores principales: Fields, Mark A., Bowrey, Hannah E., Gong, Jie, Moreira, Ernesto F., Cai, Hui, Del Priore, Lucian V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432172/
https://www.ncbi.nlm.nih.gov/pubmed/28505174
http://dx.doi.org/10.1371/journal.pone.0177763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432172/
https://www.ncbi.nlm.nih.gov/pubmed/28505174
http://dx.doi.org/10.1371/journal.pone.0177763

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