Overexpression of pyruvate dehydrogenase kinase 1 in retinoblastoma: A potential therapeutic opportunity for targeting vitreous seeds and hypoxic regions

Pyruvate dehydrogenase kinase 1 (PDK1), a key enzyme implicated in metabolic reprogramming of tumors, is induced in several tumors including glioblastoma, breast cancer and melanoma. However, the role played by PDK1 is not studied in retinoblastoma (RB). In this study, we have evaluated the expressi...

Descripción completa

Detalles Bibliográficos
Autores principales: Sradhanjali, Swatishree, Tripathy, Devjyoti, Rath, Suryasnata, Mittal, Ruchi, Reddy, Mamatha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432179/
https://www.ncbi.nlm.nih.gov/pubmed/28505181
http://dx.doi.org/10.1371/journal.pone.0177744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432179/
https://www.ncbi.nlm.nih.gov/pubmed/28505181
http://dx.doi.org/10.1371/journal.pone.0177744

Ejemplares similares