Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice

Liposarcoma is an often fatal cancer of fat cells. Mechanisms of liposarcoma development are incompletely understood. The cleavage of fatty acids from acylglycerols (lipolysis) has been implicated in cancer. We generated mice with adipose tissue deficiency of two major enzymes of lipolysis, adipose...

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Detalles Bibliográficos
Autores principales: Wu, Jiang Wei, Preuss, Christoph, Wang, Shu Pei, Yang, Hao, Ji, Bo, Carter, Gregory W., Gladdy, Rebecca, Andelfinger, Gregor, Mitchell, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432192/
https://www.ncbi.nlm.nih.gov/pubmed/28459858
http://dx.doi.org/10.1371/journal.pgen.1006716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432192/
https://www.ncbi.nlm.nih.gov/pubmed/28459858
http://dx.doi.org/10.1371/journal.pgen.1006716

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