CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15–19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70...

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Autores principales: Ulasov, Ilya V., Kaverina, Natalya V., Ghosh, Dhimankrishna, Baryshnikova, Marya A., Kadagidze, Zaira G., Karseladze, Apollon I., Baryshnikov, Anatoly Y., Cobbs, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432232/
https://www.ncbi.nlm.nih.gov/pubmed/27517625
http://dx.doi.org/10.18632/oncotarget.11175
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author Ulasov, Ilya V.
Kaverina, Natalya V.
Ghosh, Dhimankrishna
Baryshnikova, Marya A.
Kadagidze, Zaira G.
Karseladze, Apollon I.
Baryshnikov, Anatoly Y.
Cobbs, Charles S.
author_facet Ulasov, Ilya V.
Kaverina, Natalya V.
Ghosh, Dhimankrishna
Baryshnikova, Marya A.
Kadagidze, Zaira G.
Karseladze, Apollon I.
Baryshnikov, Anatoly Y.
Cobbs, Charles S.
author_sort Ulasov, Ilya V.
collection PubMed
description Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15–19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.
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spelling pubmed-54322322017-05-17 CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy Ulasov, Ilya V. Kaverina, Natalya V. Ghosh, Dhimankrishna Baryshnikova, Marya A. Kadagidze, Zaira G. Karseladze, Apollon I. Baryshnikov, Anatoly Y. Cobbs, Charles S. Oncotarget Research Paper Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15–19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness. Impact Journals LLC 2016-08-10 /pmc/articles/PMC5432232/ /pubmed/27517625 http://dx.doi.org/10.18632/oncotarget.11175 Text en Copyright: © 2017 Ulasov et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Ulasov, Ilya V.
Kaverina, Natalya V.
Ghosh, Dhimankrishna
Baryshnikova, Marya A.
Kadagidze, Zaira G.
Karseladze, Apollon I.
Baryshnikov, Anatoly Y.
Cobbs, Charles S.
CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy
title CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy
title_full CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy
title_fullStr CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy
title_full_unstemmed CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy
title_short CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy
title_sort cmv70-3p mirna contributes to the cmv mediated glioma stemness and represents a target for glioma experimental therapy
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432232/
https://www.ncbi.nlm.nih.gov/pubmed/27517625
http://dx.doi.org/10.18632/oncotarget.11175
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