Cargando…

microRNA-302c-3p inhibits renal cell carcinoma cell proliferation by targeting Grb2-associated binding 2 (Gab2)

The expression and biological function of Grb2-associated binding 2 (Gab2) in renal cell carcinoma (RCC) cells was tested here. We showed that Gab2 expression was significantly elevated in human RCC tissues and RCC cells. It was correlated with over-activation of Akt and downregulation of microRNA-3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gu, Dong-Hua, Mao, Jia-Hui, Pan, Xiao-Dong, Zhu, Hua, Chen, Xinfeng, Zheng, Bing, Shan, Yuxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432261/ https://www.ncbi.nlm.nih.gov/pubmed/28412750 http://dx.doi.org/10.18632/oncotarget.15463

Ejemplares similares

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2
por: Malagrinò, Francesca, et al.
Publicado: (2020)

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses
por: Schaeper, Ute, et al.
Publicado: (2000)

Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2
por: Toto, Angelo, et al.
Publicado: (2017)

Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in Inflammatory Signaling and Endothelial Dysfunction
por: Kondreddy, Vijay, et al.
Publicado: (2021)

MicroRNA-218 inhibits tumor angiogenesis of human renal cell carcinoma by targeting GAB2
por: Mu, Lijun, et al.
Publicado: (2020)

MicroRNA-218 inhibits tumor angiogenesis of human renal cell carcinoma by targeting GAB2
por: Mu, Lijun, et al.
Publicado: (2022)

Regulation of microRNA expression by the adaptor protein GRB2
por: Stainthorp, Amy K., et al.
Publicado: (2023)

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
por: Bongartz, Hannes, et al.
Publicado: (2019)

Structural basis for the oncogenic signalling complex formed by Grb2 and Gab2 in Her2 (ErbB2/Neu)-driven breast cancers and CML cells
por: Tsirka, T, et al.
Publicado: (2009)

Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells
por: Dou, Xiaoqian, et al.
Publicado: (2022)

Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo
por: Pan, Xiao-dong, et al.
Publicado: (2017)

MicroRNA-150 suppresses cell proliferation and metastasis in hepatocellular carcinoma by inhibiting the GAB1-ERK axis
por: Sun, Wei, et al.
Publicado: (2016)

Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina
por: Rajala, Ammaji, et al.
Publicado: (2013)

Identification of GRB2 and GAB1 Coexpression as an Unfavorable Prognostic Factor for Hepatocellular Carcinoma by a Combination of Expression Profile and Network Analysis
por: Zhang, Yanqiong, et al.
Publicado: (2013)

MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer
por: Zhang, Gui-Ming, et al.
Publicado: (2015)

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8(+) T-Cell Activation
por: Wang, Zhengqi, et al.
Publicado: (2019)

MicroRNA-485 plays tumour-suppressive roles in colorectal cancer by directly targeting GAB2
por: Li, Jibin, et al.
Publicado: (2022)

Correction: MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer
Publicado: (2020)

The microRNA and the perspectives of miR-302
por: Chen, Emily Yen Yu, et al.
Publicado: (2019)

MicroRNA-302b suppresses cell proliferation by targeting EGFR in human hepatocellular carcinoma SMMC-7721 cells
por: Wang, Lumin, et al.
Publicado: (2013)

Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology
por: Zou, Fanggeng, et al.
Publicado: (2013)

MicroRNA-200a Regulates Grb2 and Suppresses Differentiation of Mouse Embryonic Stem Cells into Endoderm and Mesoderm
por: Liu, Yang, et al.
Publicado: (2013)

Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation
por: Tan, Wan Hua, et al.
Publicado: (2013)

miR-564 inhibits hepatocellular carcinoma cell proliferation and invasion by targeting the GRB2-ERK1/2-AKT axis
por: Liang, Chaojie, et al.
Publicado: (2017)

Effect of miR-302b MicroRNA Inhibition on Chicken Primordial Germ Cell Proliferation and Apoptosis Rate
por: Lázár, Bence, et al.
Publicado: (2021)

Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation
por: Jia, Pifeng, et al.
Publicado: (2017)

Application of the microRNA‐302/367 cluster in cancer therapy
por: Liu, Jiajia, et al.
Publicado: (2020)

MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells
por: Kim, J Y, et al.
Publicado: (2014)

MicroRNA-200a Suppresses Cell Invasion and Migration by Directly Targeting GAB1 in Hepatocellular Carcinoma
por: Wang, Jianlin, et al.
Publicado: (2017)

MicroRNA-302a-3p suppresses hepatocellular carcinoma progression by inhibiting proliferation and invasion
por: Ye, Ying, et al.
Publicado: (2018)

GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers
por: Park, Yu Rang, et al.
Publicado: (2017)

MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells
por: Parr, Callum J. C., et al.
Publicado: (2016)

miR-302 Suppresses the Proliferation, Migration, and Invasion of Breast Cancer Cells by Downregulating ATAD2
por: Hwang, Yo Sep, et al.
Publicado: (2022)

MicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial–mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells
por: Li, Yibing, et al.
Publicado: (2018)

Down-Regulation of Gab1 Inhibits Cell Proliferation and Migration in Hilar Cholangiocarcinoma
por: Sang, Haiquan, et al.
Publicado: (2013)

MicroRNA 302b-3p/302c-3p/302d-3p inhibits epithelial–mesenchymal transition and promotes apoptosis in human endometrial carcinoma cells [Erratum]
Publicado: (2018)

Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation
por: Zheng, Bing, et al.
Publicado: (2016)

Grb2 binding induces phosphorylation-independent activation of Shp2
por: Lin, Chi-Chuan, et al.
Publicado: (2021)

MicroRNA-137 suppresses the proliferation, migration and invasion of cholangiocarcinoma cells by targeting WNT2B
por: Chen, Tengxiang, et al.
Publicado: (2020)

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma
por: DONG, YE, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cqddblm79cpdjpjl0epkrhru90