A One-Pot Three-Component Double-Click Method for Synthesis of [(67)Cu]-Labeled Biomolecular Radiotherapeutics

A one-pot three-component double-click process for preparing tumor-targeting agents for cancer radiotherapy is described here. By utilizing DOTA (or NOTA) containing tetrazines and the TCO-substituted aldehyde, the two click reactions, the tetrazine ligation (an inverse electron-demand Diels-Alder c...

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Detalles Bibliográficos
Autores principales: Fujiki, Katsumasa, Yano, Shinya, Ito, Takeshi, Kumagai, Yuki, Murakami, Yoshinori, Kamigaito, Osamu, Haba, Hiromitsu, Tanaka, Katsunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432496/
https://www.ncbi.nlm.nih.gov/pubmed/28507297
http://dx.doi.org/10.1038/s41598-017-02123-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432496/
https://www.ncbi.nlm.nih.gov/pubmed/28507297
http://dx.doi.org/10.1038/s41598-017-02123-2

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