Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and i...

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Detalles Bibliográficos
Autores principales: Niego, Be’eri, Lee, Natasha, Larsson, Pia, De Silva, T. Michael, Au, Amanda E-Ling, McCutcheon, Fiona, Medcalf, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433693/
https://www.ncbi.nlm.nih.gov/pubmed/28510599
http://dx.doi.org/10.1371/journal.pone.0177332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433693/
https://www.ncbi.nlm.nih.gov/pubmed/28510599
http://dx.doi.org/10.1371/journal.pone.0177332

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