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Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin
Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of nonselective ROCK inhibitors like fasudil together with rt-PA may be hindered by possible hypotensive side-effects and i...
Autores principales: | Niego, Be’eri, Lee, Natasha, Larsson, Pia, De Silva, T. Michael, Au, Amanda E-Ling, McCutcheon, Fiona, Medcalf, Robert L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433693/ https://www.ncbi.nlm.nih.gov/pubmed/28510599 http://dx.doi.org/10.1371/journal.pone.0177332 |
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