SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands

The neurotensin receptor 1 represents an important drug target involved in various diseases of the central nervous system. So far, the full exploitation of potential therapeutic activities has been compromised by the lack of compounds with favorable physicochemical and pharmacokinetic properties whi...

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Detalles Bibliográficos
Autores principales: Huber, Sylwia, Casagrande, Fabio, Hug, Melanie N., Wang, Lisha, Heine, Philipp, Kummer, Lutz, Plückthun, Andreas, Hennig, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433701/
https://www.ncbi.nlm.nih.gov/pubmed/28510609
http://dx.doi.org/10.1371/journal.pone.0175842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433701/
https://www.ncbi.nlm.nih.gov/pubmed/28510609
http://dx.doi.org/10.1371/journal.pone.0175842

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